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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

F. Minoxidil (Vectors):

Minoxidil, a polyol compound, is used to improve blood flow to treat erectile dysfunction. While this polyol may be cause for concern, Minoxidil's polyol effects can increase the risk of side effects, such as low blood pressure, which can be uncomfortable or embarrassing. If you are using Minoxidil with Cialis or any other erectile dysfunction products, it is recommended to avoid. With Minoxidil, the polyol component of Minoxidil is retained in the body for longer, leading to improved blood flow.

C. Viagra and Cialis:

Viagra and Cialis can affect the blood-pressure-lowering effects of Viagra, leading to symptoms like dizziness, lightheadedness, or fainting. If you are using Viagra with Cialis or Cialis products, it is recommended to avoid. Viagra with Cialis or Cialis products should be avoided as it may increase the risk of side effects.

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Use caution when ordering from eDrugstore.com

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Last updated 13 November 2023

Generic tadalafil is now available in the UK

For pricing and information please click the button below:

The so-called ‘weekend pill’ will soon be made by generic manufacturers, as Eli Lilly’s patent on the drug is expected to expire in the UK 14 November 2017, and will be made available soon after from.

The patent for Cialis expired in March 2015 in Brazil, and is now available in that country as generic tadalafil from Sandoz.

Cialis comes onto the scene

Containing the active ingredienttadalafil, Cialis was, to compete with Pfizer’s erectile dysfunction medicine Viagra. It was originally developed to relieve frequent urination or weak flow of urine in patients with enlarged prostates, but it also helps increase blood flow to the penis.

Why Cialis?

Cialis, Viagra and several other ED medicines are phosphodiesterase-5 (PDE5) inhibitors, which work by inhibiting the enzyme that regulates blood flow to the penis. The principal difference with Cialis is its duration.Unlike Viagra and Levitra, which last for about 4 and 12 hours respectively, Cialis lasts for about 36 hours.Patients will not have a continuous erection, but can achieve one when sexually stimulated throughout that time frame. Under ideal circumstances, a man can buy Cialis to take on a Friday and still experience the effects on Sunday morning.

The extended duration has the potential to allow couples to be more spontaneous than with other ED drugs, which must be taken an hour or so before sexual activity. Cialis can also be taken in lower daily doses of 2.5–5mg, to allow for continuous treatment of ED.

Tadalafil: Generic Cialis

When Pfizer, other manufacturers began making generic sildenafil, resulting in a dramatic reduction in price, and the same can reasonably be expected for Cialis.

When developing a new drug for release to the market, drug companies choose a brand name for the medicine. It is then often prescribed by doctors by its name. Upon expiry of the patent, competing drug companies can then create a generic version of the medicine, assigning it a new brand name or just using the name of the active ingredient. Patients may soon be able to buy generic Cialis simply under the name ‘Tadalafil’.

Only the 5mg, 10mg and 20mg strengths of generic Cialis will be available from 14 November 2017.

Will generic Cialis be the same?

may differ in their packaging or in the size or shape of the tablets, but they are required to be medically the same as their branded equivalents. The dosages, effects and active ingredients are the same. Quality assurance of both branded and generic medicines is carried out by the European Medicines Agency in London or by the governing authorities in member countries where the medicine is sold.

Cialis without a prescription

In 2014 the French drug company Sanofi reached an agreement with Eli Lilly to apply to provide Cialiswithout a prescriptionin the United States, Canada, Australia, and Europe. As quoted in a press release by Eli Lilly, “Sanofi anticipates providing Cialis OTC after expiration of certain patents,” though terms of the licensing agreement were not disclosed, and the application would face significant regulatory hurdles.

This could have a dramatic effect on the drug’s competition with Viagra, considering the stigma attached to erectile dysfunction and many men’s hesitance to discuss it with their doctors. Although sildenafil, branded Cialis, and other ED medicines can be acquired through a face-to-face consultation with a GP or pharmacist, or by following a simple with a pharmacy such as Dr Fox, having the medicine available without a prescription will make it even easier to obtain.

Update September 2023:and both now available without prescription.

In this case patients can also expect to respond with competitive pricing to buy generic Cialis, and the same straightforward ordering process that has attracted patients to purchase medicine online in the past.

Cialis is know as the ‘weekend pill’ due to its 36 hour duration of action. It is made by the brand new generic version after a significant adjustment in the selection process has been made.

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